RESEARCH

We study fundamental principles that regulate phenotypic, metabolic, and morphogenetic processes in early embryonic patterning; and, the causal mechanisms when these dynamic processes go awry. Our work represents a new paradigm in developmental biology, where traditional genetic-focused perspectives are enriched by a deep understanding of the metabolic context driving these processes.
By combining studies involving the mouse and human embryos, and their in vitro 3D stem cell models, our laboratory explores the molecular landscape that directs differentiation and developmental programming in health and disease.